Linear regression analysis of absolute and age-adjusted telomere fluorescence in granulocytes and lymphocytes from patients with untreated or refractory AA.

Linear regression analysis of absolute (panels A and C) and age-adjusted (panels B and D) telomere fluorescence in granulocytes (panels A and B) and lymphocytes (panels C and D) from patients with untreated (sAA/mAA) or refractory (sAANR) AA measured by flow FISH. Note that no significant decline was found in absolute telomere length with age in granulocytes (panel A) whereas absolute lymphocyte telomere length declined at slightly lower rate than in controls (panel C) and that age-adjusted telomere length in granulocytes amounts to approximately − 5000 MESF at birth but increases with age (panel B).