Fig. 1.
Fig. 1. Mean values (%) of both Fas and Fas-L expressed by bone marrow plasma cells and erythroblasts. / Nineteen patients with MM and 5 patients with MGUS were grouped in relation to their clinical stages. (A) A remarkable up-regulation of Fas-L was detected in plasma cells from patients with stage III MM as compared with the MGUS controls. This pattern was associated with a concurrent increase of Fas+ erythroblasts, whose defective expression of Fas-L in patients with advanced disease suggested the depletion of mature erythroblasts in the bone marrow. Note the decreasing Fas expression by myeloma cells with disease progression. The evaluation was carried out by double fluorescence analysis using CD38 bright and GpA as phenotypic markers of plasma cells and erythroblasts, respectively. (B) Correlation of individual Hb values with the relative expression of both Fas+ and Fas-L+ fresh plasma cells and erythroblasts (graphic representation of Spearman's test). The analysis revealed an inverse correlation of Hb levels with the percent expression of either Fas-L+ plasma cells or Fas+erythroblasts.

Mean values (%) of both Fas and Fas-L expressed by bone marrow plasma cells and erythroblasts.

Nineteen patients with MM and 5 patients with MGUS were grouped in relation to their clinical stages. (A) A remarkable up-regulation of Fas-L was detected in plasma cells from patients with stage III MM as compared with the MGUS controls. This pattern was associated with a concurrent increase of Fas+ erythroblasts, whose defective expression of Fas-L in patients with advanced disease suggested the depletion of mature erythroblasts in the bone marrow. Note the decreasing Fas expression by myeloma cells with disease progression. The evaluation was carried out by double fluorescence analysis using CD38 bright and GpA as phenotypic markers of plasma cells and erythroblasts, respectively. (B) Correlation of individual Hb values with the relative expression of both Fas+ and Fas-L+ fresh plasma cells and erythroblasts (graphic representation of Spearman's test). The analysis revealed an inverse correlation of Hb levels with the percent expression of either Fas-L+ plasma cells or Fas+erythroblasts.

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