SU5416 and SU6668 inhibit SCF-induced proliferation of MO7E cells.

MO7E cells were quiesced by serum starvation overnight in medium containing 0.1% FBS. Cells were plated in triplicate in 96-well plates and pretreated for 30 minutes with the indicated concentrations of SU5416 or overnight with SU6668 or SU-A. Cells were incubated with 10 ng/mL SCF in the presence of compound for 48 hours, followed by MTT analysis. Percent growth relative to the untreated control was calculated based on the MTT readout.