Inhibition of c-kit signaling induces apoptosis in MO7E cells.

MO7E cells were quiesced by serum starvation overnight in medium containing 0.1% FBS and were untreated (A) or treated with 100 ng/mL SCF (B), SCF plus an SCF-neutralizing antibody (SCF-N) (C) or an isotype control E-cadherin antibody (Ctl Ab) (D), or camptothecin (E). At 24 hours, samples were stained with PE-conjugated antiactivated caspase-3 antibody and quantitated by fluorescence-activated cell sorter analysis. The asterisk indicates the apoptotic population.