SU5416- and SU6668-treated MO7E cells demonstrate increased expression of activated caspase-3.

MO7E cells were quiesced by serum starvation overnight in medium containing 0.1% FBS and were pretreated for 30 minutes with the indicated concentrations of SU5416 (A), or 24 hours with SU6668 (B), followed by addition of 100 ng/mL SCF; untreated samples were treated with SCF only. At 24 hours, samples were stained with PE-conjugated antiactivated caspase-3 antibody and quantitated by fluorescence-activated cell sorter analysis. The asterisk indicates the apoptotic population.