Fig. 5.
In vivo persistence of NS3623 induced gCl-block.
Inhibition of erythrocyte Cl-conductance by NS3623 at varied doses (10-400 mg/kg) and times (2-24 hours), as indicated on the individual curves, after PO administration of NS3623 to normal mice. Protocol as in Figure 3. Con, control mice; Veh, Cremophore. Individual columns represent hyperpolarizations of RBCs from 3 mice, mean ± SD. Arrows show the hyperpolarization at normal chloride conductance (mean of control hyperpolarizations).
