Taxol and epirubicin time-dependently induce DNA fragmentation in B-lymphoid cells.

Cells were treated with control medium (Co), 0.1 μg/mL Taxol (T), or 1 μg/mL epirubicin (E). DNA fragmentation was measured in drug-treated BJAB cells (A) after the indicated time, in NALM-6 cells (B) after 48 hours, and in REH cells (C) after 48 hours as described in “Materials and methods.” Values are given as percentage of specific apoptosis ± SD (n = 3).