Time-course of Taxol- and epirubicin-induced caspase-3– and caspase-8–like activity in BJAB cells.

BJAB cells were cultured in control medium, 0.1 μg/mL Taxol (T), or 1 μg/mL epirubicin (E) for different time intervals as indicated. Caspase-3–like activity was determined as described in “Materials and methods” using Ac-DEVD-pNA (A). Caspase-8–like activity was assessed in parallel using Ac-IETD-pNA (B). Caspase-3– and caspase-8–like activities are given as percentage of control ± SD (n = 3).