Histologic analysis of transplanted and untreated control MPS VII mice.

(A-F) Frozen tissue sections stained with naphthol AS-BI β-d-glucuronide and counterstained with methyl green. Donor-derived pink/red GUS⁺ cells can easily be seen in the tissues of the transplant recipients. (G-L) Microscopic analysis of fixed tissues showing the reduction in lysosomal GAG storage. Tissues from the transplant recipients have reduced amounts of distended lysosomal “foamy” structures as compared to the untreated controls (see arrows).