Fig. 6.
Effect of drug concentration on radioiron mobilization from cultured, iron-loaded heart cells.
Five-day-old cultures were first incubated with 360 μM59Fe-labeled ferric ammoniun citrate for 24 hours, washed, and then exposed for an additional 24 hours to 20 to 320 μM deferoxamine (DFO), ICL670A (ICL), or both (ICL+DFO). The molar strength of the mixed DFO+ICL670A solution was identical with the corresponding single drug treatment and consisted of a 1:1 molar ratio of the 2 compounds. Results expressed as percent or total cellular radioactivity in untreated controls. Each point represents the mean ± 1 SD of 6 cultures.
