Fig. 2.
RARα−/− myeloid progenitors are resistant to the inhibitory effects of 9C-RA.
(A) Numbers of colonies developing from 5 × 104 BM cells from WT or RARα−/− mice in the presence or absence of 10−6 M 9C-RA. Each bar represents the average of duplicate samples from 3 mice. The cytokines used to stimulate growth of hematopoietic progenitors were SCF, IL-6, IL-3, and EPO. (B) Representative colonies (day 7) showing the reduction in size of WT granulocyte colonies grown in the presence of 9C-RA and the lack of such an effect in RARα−/− mutants.
