Demonstration of abundant VEGF mRNA and protein signals in neoplastic myelomonocytic leukemia cells (CMML).

(upper left) Hematoxylin and eosin staining. (upper right) IHC demonstrating strong VEGF protein expression. (lower left) Poly d(T) staining confirming integrity of total mRNA. (lower right) ISH demonstrating strong expression of the VEGF message in a patient with CMML (1000 × magnification).