Multimer analysis of vWF in patient 0103 with vWD 2A/IIE and patient 0203 with vWD 3.

(Top) Characteristic for vWD 2A/IIE are the lack of HMWM, the lack of a triplet structure (indicating decreased proteolysis), and the presence of the defect in both the patient's plasma (pla) and platelets (plt). (Bottom) Multimer analysis of vWF derived from platelets from the patient with vWD 3 (0203) compared with a normal (N) control. Bands corresponding to low-molecular-weight vWF (arrows) appeared only after prolonged exposure of the film, indicating a very low concentration of vWF. The 0201 indicates vWF multimer pattern of the heterozygous father's plasma. Arrows point to extra intervening bands between triplets.