Histopathology of MPD induced by tyrosine kinase fusions in the absence of GM-CSF and IL-3.

TEL/JAK2 (T/J), TEL/PDGFβR (T/P), TEL/TRKC (T/T). MPD is manifested in each case by destructive infiltration of the liver, and replacement of normal hematopoietic elements in the bone marrow and spleen by myeloid lineage cells, including many mature granulocytes. The T/J liver panel is magnified at low power (10×), all other panels are magnified at high power (100×). All panels are views of tissues stained with hematoxylin and eosin.