Competitive repopulation with GM-CSF versus TEL/PDGFβR.

Wild-type Balb/c bone marrow transduced with GM-CSF or TEL/PDGFβR was combined with wild-type Balb/c bone marrow transduced with EGFP alone and was transplanted into lethally irradiated syngeneic mice. After development of MPD evidenced by splenomegaly, splenocytes from GM-CSF plus EGFP mice (top panels) and TEL/PDGFβR plus EGFP mice (bottom panels) were assayed for expression of EGFP. Input populations of cells were 5% GM-CSF with 95% EGFP (upper left), 25% GM-CSF with 75% EGFP (upper right), 5% TEL/PDGFβR with 95% EGFP (lower left), and 50% TEL/PDGFβR with 50% EGFP (lower right).