Fig. 3.
![Fig. 3. Tax inhibits Smad-induced responses to TGF-β. / Either pH2Rneo ([■], −Tax) or pH2R40M ([▪], +Tax), in combination with p3TP-Lux, was transfected into HepG2 cells, together with the indicated Smad constructs in the absence or the presence of 10 ng/mL TGF-β. Relative luciferase activities were measured in cell extracts, normalized to the renilla luciferase activity. Luciferase activity is presented as fold induction relative to the basal level measured in cells transfected with p3TP-Lux alone without treatment. Data represent the mean ± SD from 3 separate experiments.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/97/7/10.1182_blood.v97.7.2137/6/h80710845003.jpeg?Expires=1735595449&Signature=IAI6hoqdqgX0LDxUIxqPyazpMNg7rdRjo-7JhoOpSmhffIezFXAgZ4aMRzTuOvYvB59PXolm5MVei9eT8HKTy9ik56-qUkaEogx6RM6M~4dXxMHTBkXuGvK7nXkNh5qc9m1wt-xaAcLQNY9gF2af45Kc94i0wfM3TvX8inp8l87ZOtOYekSc-2XWN~NFOmpaQNmTQid-8Oi0w~mxV-UYdJ83ysEfXXQquE5gX1QT1ZrNv0g7STosaK7zeBtRXig~vCDAY6vmbs6wa0Hn53i4JmUfC8nc-ahu562IYPA7zf8HES114w-nzpd-1ctofG8RhlVM9h48C-GqC6E6aMEGug__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Tax inhibits Smad-induced responses to TGF-β.
Either pH2Rneo ([■], −Tax) or pH2R40M ([▪], +Tax), in combination with p3TP-Lux, was transfected into HepG2 cells, together with the indicated Smad constructs in the absence or the presence of 10 ng/mL TGF-β. Relative luciferase activities were measured in cell extracts, normalized to the renilla luciferase activity. Luciferase activity is presented as fold induction relative to the basal level measured in cells transfected with p3TP-Lux alone without treatment. Data represent the mean ± SD from 3 separate experiments.
