Fig. 7.
Fig. 7. Analysis of VEGF-induced vascular permeability in vivo. / VEGF-induced vascular permeability in BALB/c mice pretreated (30 minutes) with TAPI or solvent (A) or the SAPK-2/p38 specific inhibitor SB203580 (VEGF plus SB) or solvent (VEGF) (B). Shown are scatter diagrams with each symbol representing the ratio between the VEGF- and PBS-treated ear of one tested animal. Depicted are the mean (line) and the significance (P values) as calculated from an unpaired t test using a commercial program (InStat 2.01). Note the different y-axis scales. Although variations between the values of individual animals were observed, probably due to injuries of small capillaries during injections, the differences between the individual groups were highly significant.

Analysis of VEGF-induced vascular permeability in vivo.

VEGF-induced vascular permeability in BALB/c mice pretreated (30 minutes) with TAPI or solvent (A) or the SAPK-2/p38 specific inhibitor SB203580 (VEGF plus SB) or solvent (VEGF) (B). Shown are scatter diagrams with each symbol representing the ratio between the VEGF- and PBS-treated ear of one tested animal. Depicted are the mean (line) and the significance (P values) as calculated from an unpaired t test using a commercial program (InStat 2.01). Note the different y-axis scales. Although variations between the values of individual animals were observed, probably due to injuries of small capillaries during injections, the differences between the individual groups were highly significant.

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