Effects of 5-HT on PAI-1 and TPA mRNA expression.

(A) Dose-dependent effects of 5-HT. (B) Time-dependent effects of 5-HT. Graph showing relative PAI-1 (▪) and TPA (■) mRNA expression represents the fold increase in corrected PAI-1 and TPA mRNA expression compared to vehicle-treated controls, respectively. Each bar represents the mean ± SEM of 3 independent experiments (*P < .05 versus vehicle-treated controls).