Correlation of anticoagulant response to APC:protein S with plasma GlcCer levels in patients with venous thrombosis.

Fasting plasma samples from 50 patients with venous thrombosis and 50 controls were assayed using modified PT clotting assays21in the presence and absence of added APC:protein S. Baseline PT values were determined in the absence of added APC:protein S. Parameters from analysis of the correlation between the observed clotting times and GlcCer are shown for each subgroup. (A) PT in the presence of added APC:protein S for patients with venous thrombosis (excluding those with Q506–factor V); (B) PT in the presence of added APC:protein S for controls (excluding those with Q506–factor V); (C) baseline PT for thrombosis patients; and (D) baseline PT for control subjects.