TIMP-1 induces IL-10 expression.

(A) TIMP-1 and IL-10 expression in Burkitt lymphoma lines. A series of Burkitt lymphoma cell lines was examined for secreted TIMP-1 (▪) and IL-10 (■). All ELISA determinations were performed 3 times, with triplicate samples within each determination. (B) TIMP-1 induction of IL-10. LXSN retroviral transduction was used to induce TIMP-1 expression in the TIMP-1⁻ cell line JD38 and IL-10 secretion measured by ELISA (y-axis).