Limited expression of PDGF-B and PDGFRβ in E14.5 fetal mouse livers.

Nonradioactive in situ hybridization shows PDGF-B expression in a subset of liver cells (A, arrows), which have the morphologic hallmarks of megakaryocytes (B, arrow). PDGFRβ expression is low in the liver (C, Li), in comparison with the adjacent adrenal (C, Ad), in which abundant positive cells with perivascular location are seen (arrowheads). The developing hepatic connective tissue capsule expresses PDGFRβ, as shown in the homogeneous layer of stained cells between the liver tissue and the adrenal.