Comparison of the effects of different NSAIDs on IL-2 and IL-4 secretion from CD4⁺ PBT.

Purified PBT (≥ 97% CD3⁺CD4⁺) were treated with optimal concentrations of ASA (10⁻³ M), SA (10⁻³ M), IM (10⁻⁵ M), and FBP (10⁻⁵ M) or corresponding amounts of DMSO carrier (up to 0.1%) before stimulation with PMA (10 ng/mL) and A23187 (0.5 mg/mL). The mean ± SEM percentage of control IL-4 (▪, 572.4 ± 26.2 pg/mL) and IL-2 (■, 194.8 ± 43.4 U/mL) secretion in 4 independent experiments done in duplicate is shown. The asterisk indicatesP < .05 (Wilcoxon test) relative to DMSO-treated controls.