Syk and Src-like tyrosine kinases are respectively involved in the s-FKN–induced ERKs and p38 activations.

MonoMac6 cells, untreated or preincubated 2 hours with 10 μM PP2 or 5 μg/mL piceatannol, were exposed following different time courses to 60 nM s-FKN. The activity and the amount of each MAPK were evaluated as described in “Materials and methods.” The results are representative of 3 experiments.