Genomic organization of the bleeding disorder candidate region.

(A) The critical region for the disease gene between the markers D1S433 and TMG86 spanning an interval of 1.47 cM. (B) The region covered by the PAC contig 195 from the Sanger Center. (C) The markers used for genotyping (D), PACs, and BACs included in the contig 195, representing the tiling path. The contig contains mainly Sanger Centre clones, with minor gaps filled by BACs from other centers (267L3, Whitehead Institute/MIT Genome Center, Cambridge, MA, and 319D10, Washington University Genome Sequencing Center, St Louis, MO). Black boxes, PACs with completed and fully analyzed sequences; patterned boxes, PACs and BACs with working draft sequences; and grey boxes, BACs in the initial stages of sequencing. (E) The candidate genes in the critical region.