Fig. 3.
![Fig. 3. Synergistic inhibitory effects of STI571 and AG490 on BCR-ABL-expressing cell lines. / (A) Experiments using the cell line FDrv210H (18-hour incubation in inhibitors), titrating STI571 in a constant concentration of AG490. In panels A and B, solid (+IL-3) and open (−IL-3) symbols identify curves for varying concentrations of AG490 alone (●,○) STI571 alone (▴,▵), and serial dilutions of STI571 in a constant concentration AG490 [5 μM] (♦,⋄). (B) Experiment using the cell line 32Dp210 (18-hour incubation in inhibitors), titrating STI571 in a constant concentration of AG490. (C) For a constant STI571 concentration (0 or 0.01 μM), AG490 was added at the concentrations shown (MO7p210 cell line; 18-hour incubation in inhibitors without GM-CSF).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/97/7/10.1182_blood.v97.7.2008/6/h80710843003.jpeg?Expires=1735824881&Signature=1El-E69PBb2ughaKjhIJ1f5iDk9P~QPp8N0CLbQ8USzUSNmFUFHovaLvxcMWo1uFiQLJPG4V-lIzx6CdmcD~46160XEmm1AZozM3sdJvCouWNWoc62e66Q~vbESclhqz0x~hlKKvTJRDOIf31h-vhjj~9CZ0TTaVChKMC~KRaEvQDoUsyyATH29EwVn~G74~AafXfLmy7fKV~bSBLFLGMPVu7qlrE~NyMswy4Q2yZjTOY4t6ta8A7DJ-YmpD-N8eSpamjS2xGODnMH0XTkK~G48iYn0knQo5BZW8yyjVWQCFyuh~s1ukjLXvQqGAMErO~64opGjfiAYh~rOEv2Po5w__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Synergistic inhibitory effects of STI571 and AG490 on BCR-ABL-expressing cell lines.
(A) Experiments using the cell line FDrv210H (18-hour incubation in inhibitors), titrating STI571 in a constant concentration of AG490. In panels A and B, solid (+IL-3) and open (−IL-3) symbols identify curves for varying concentrations of AG490 alone (●,○) STI571 alone (▴,▵), and serial dilutions of STI571 in a constant concentration AG490 [5 μM] (♦,⋄). (B) Experiment using the cell line 32Dp210 (18-hour incubation in inhibitors), titrating STI571 in a constant concentration of AG490. (C) For a constant STI571 concentration (0 or 0.01 μM), AG490 was added at the concentrations shown (MO7p210 cell line; 18-hour incubation in inhibitors without GM-CSF).
