Morphology of cell lines incubated with AG957, AG490, and STI571 for 18 hours.

May-Grunwald-Giemsa stained cytospin preparations of cells incubated for 18 hours in media with FCS, growth factor, and inhibitor concentrations as listed. (A) FDC-P1 cells, 10% FCS + IL-3, no inhibitors. (B) FDC-P1 cells, 0.5% FCS + IL-3, no inhibitors. (C) FDC-P1 cells, 0.5% FCS + IL-3, STI571 = 10 μM. (D) FDC-P1 cells, 0.5% FCS + IL-3, AG957 = 50 μM. (E) FDrv210H cells, 10% FCS no IL-3, no inhibitors, (F) FDrv210H cells, 0.5% FCS no IL-3, no inhibitors. (G) FDrv210H cells, 0.5% FCS + IL-3, no inhibitors. (H) FDrv210H cells, 0.5% FCS + IL-3, AG490 = 5 μM. (I) FDrv210H cells, 0.5% FCS no IL-3, STI571 = 10 μM; arrows indicate 2 cells with fragmenting apoptotic nuclei. (J) FDrv210H cells, 0.5% FCS + IL-3, STI571 = 10 μM; arrow indicates one cell with fragmented apoptotic nucleus. (K) FDrv210H cells, 0.5% FCS no IL-3, AG957 = 50 μM. (L) FDrv210H cells, 0.5% FCS + IL-3, AG957 = 50 μM.