Abnormal intracellular kinetics of cell-cycle–dependent proteins in lymphocytes from HIV- infected patients.

AgNOR pattern and C23/nucleolin subcellular localization after in vitro activation of lymphocytes from healthy controls (panel A) and HIV-infected individuals (panel B). The indexes of the functional status of the maturation promoting factor (cyclin B expression and ubiquitination, cdc25 expression and ubiquitination, and p34 cdc2 activity) are relative to time 90 to 96 hours after activation.