Antigen reactivity.

(A-E) HHV-8–specific CTLp and IFN-γ production to 5 lytic cycle antigens, HHV-8 Ab titers, HHV-8 DNAemia, and signs and symptoms in subjects 20 to 24. CTLp's are shown as the closed symbols, whereas the numbers of IFN-γ–producing cells are the open symbols. SC is the estimated time of seroconversion; years are the times of the clinic visits before and after HHV-8 seroconversion; viral DNA is PCR detection of HHV-8 DNA in PBMCs; S&S represent symptoms of rash (R), fatigue (F), and diarrhea (D) reported by the study subject for the 6 month time interval before the specific visits, and signs of lymphadenopathy (L) detected on physical examination at the particular study visit.