Association of HLA class I and CD8⁺ T cells with HHV-8–specific CTL reactivity and IFN-γ production.

(A) Blockage of HHV-8–specific CTL responses to gH (▨) and MiCP (▩) by anti-HLA class I but not class II in representative subject 14. (B) Blockage of HHV-8–specific IFN-γ production induced by gB (■), gH (▨), and IE protein (▧) by anti-HLA class I but not class II Abs in representative subject 21. (C) HHV-8 specific CTL responses to gH (▨) and MiCP (▩) mediated by enriched CD8⁺ T cells, and not by enriched CD4⁺ T cells, in representative subject 14 at E:T ratios of 20:1, 10:1, and 5:1. (D) HHV-8–specific IFN-γ production induced by gB (■), gH (▨), and IE protein (▧) in enriched CD8⁺ T cells, and not in enriched CD4⁺ T cells, in representative subject 21.