Pattern analysis of CTLp and IFN-γ T-cell reactivity to the 5 HHV-8 lytic cycle antigens during HHV-8 primary infection (mean ± SE).

Time is grouped into 5 separate intervals, that is, 0, 1 to 12 months, 13 to 30 months, 31 to 40 months, and 41⁺ months. These periods were chosen in a manner designed to maximize the number of patients contributing observations to each time interval (ie, 5, 5, 5, 4, and 3 patients). When a patient contributed more than a single observation to an interval, the values were averaged. Time and HHV-8 antigen were crossed with study subject, which was treated as a random factor. This analysis demonstrated that time was the most significant predictor of the level of T-cell response (P < .001) for both the limiting dilution CTLp assay and the single-cell IFN-γ production assay. ●, gB; ■, gH; ▴, MCP; ▵, MiCP; ♦, IE.