IL-6 sustains the IL-2 generation of PCs.

Activated B cells (day 0) were cultured for up to 10 days with or without 50 U/mL IL-2, 10 ng/mL IL-6, 10 ng/mL IL-10, 50 μg/mL anti–IL-6 BE-8 mAb as indicated in the figure (A-C). (D) Activated B cells (day 0) were cultured for 7 or 10 days with 50 U/ml IL-2. As indicated, 10 ng/mL IL-6 was added either at day 0, 4, or 7; the percentage of PCs was determined at day 7 (for IL-6 added at day 0 or 4) or day 10 (for IL-6 added at day 7). Results show 3 representative experiments out of 5.