Dose-related effect of single SQ injection of SB-25153 on blood CFU-GM neutrophil mobilization in mice.

(A) Normalized CFU-GM data are presented as the number of CFU-GM mobilized per mL blood at the optimal time (15 minutes after dosing) in comparison to 2.5 mg/kg SB-251353 (100%) in the same experiment. Data are presented as the mean ± SEM of 8 experiments. All doses above 0.1 mg/kg increased CFU-GM mobilization compared with PBS controls (P < .01). Values at the 5-40 mg/kg doses were not statistically different from the 2.5 mg/kg dose (P > .05). (B) Dose-related effect of single SQ injection of SB-251353 (●) on absolute neutrophil counts. ANCs represent the peak values observed within 60 minutes after injection. Data are presented as the mean ± SEM of 3-37 experiments. *P < .01 increase in ANCs compared with PBS controls (▪). **P < .05 decrease in ANCs compared with PBS controls.