Neutrophil and platelet recovery in lethally irradiated mice that received transplantations with 2 × 106mobilized LD-PBCs from treated donor mice.
(A) Neutrophil recovery in lethally irradiated mice that received transplantations with 2 × 106 mobilized LD-PBCs from donor mice treated with PBS, SB-251353, G-CSF, and SB-251353 plus G-CSF. Each time point represents the mean ANCs of 3 mice per time point. *P < .05 increase compared with G-CSF alone. (B) Platelet recovery in lethally irradiated mice that received transplantations with 2 × 106 mobilized LD-PBCs from donor mice treated with PBS, SB-251353, G-CSF, or SB-251353 plus G-CSF. Each time point represents the mean platelet count of 3 mice per time point. *P < .05 increase compared with G-CSF alone on the indicated day. The rates of cell recovery for SB-251353 alone and in combination with G-CSF were significantly higher than cell recovery using G-CSF alone, as determined by nonlinear regression analysis based upon 4-parameter weighted fits (P < .01).
