Rescue of defective vascularity of

np-1 mutant embryos in vivo by dimer of soluble NP-1. Injection of CD4-Fc as a control had no effect (A, C). On injection of NP-1–Fc, some np-1^−/− embryos showed a substantial recovery of vascularity, and interestingly, the caliber of the rescued capillaries (B, D) was larger than those of capillaries in wild-type embryos (Figure 1A,C). Similar results were obtained in 3 independent experiments. The scale bar indicates 150 μm (A-B) or 300 μm (C-D).