Leukocyte (WBC) counts and survival of primary marrow transplant recipients.

(A) Mean WBC values for each treatment group are shown over time. Only mice receiving MFINV-TD–expressing BM displayed extremely high WBC counts initially (TD). At 1 year, mice receiving MFINV-WT transplants began to develop leukocytosis (WT). Control mice receiving empty vector–transduced BM are also shown (MINV). (B) MFINV-TD (TD) mice rapidly became moribund and required sacrifice by 6 weeks after transplantation. MFINV-WT (WT) mice became sick and died or required sacrifice at approximately 1 year after transplantation. All control (MINV) vector group mice remained alive. ○, TD, n = 5; ▪, WT, n = 4; ▵, MINV, n = 3.