Fig. 4.
Fig. 4. Abnormal pre-B-cell lineage expansions in secondary FGFR3-TD overexpressing transplant recipients. / Single-cell suspensions of BM, spleen, or PB cells from mice 6 weeks after secondary transplantation were prepared and analyzed by flow cytometry. Shown in panel A are malignant cells from an MFINV-TD recipient mouse that displayed a pre-B-cell phenotype (B220+, IgM−, CD43+/−, CD25+) in spleen. Flow cytometric analysis of spleen cells from an MFINV-WT recipient mouse, shown in panel B, demonstrated a normal pattern in this early posttransplantation period.

Abnormal pre-B-cell lineage expansions in secondary FGFR3-TD overexpressing transplant recipients.

Single-cell suspensions of BM, spleen, or PB cells from mice 6 weeks after secondary transplantation were prepared and analyzed by flow cytometry. Shown in panel A are malignant cells from an MFINV-TD recipient mouse that displayed a pre-B-cell phenotype (B220+, IgM−, CD43+/−, CD25+) in spleen. Flow cytometric analysis of spleen cells from an MFINV-WT recipient mouse, shown in panel B, demonstrated a normal pattern in this early posttransplantation period.

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