Abnormal T- and B-cell lineage expansions in secondary FGFR3-TD overexpressing transplant recipients.

Malignant cells (staining as pre-B) from a primary recipient (TD5) were transplanted into secondary recipients (TD5.1 and TD5.2). Of note, malignant populations that arose in these mice had different phenotypes. Spleen cells from the TD5.1 secondary recipient mouse exhibited an abnormal T-cell phenotype (CD3⁻, CD4⁺, CD8⁺), whereas in mouse TD5.2 the pre-B cell population continued to predominate. Analysis of the same cell populations from an empty vector MINV recipient control mouse are shown to demonstrate a normal pattern.