Fig. 7.
Fig. 7. FGFR3 is overexpressed and STAT3 and bcl-xLup-regulated in tumors originating after BM transplantation. / Western blot analysis for FGFR3 expression was performed on tissues derived from mice that developed tumors (WT1.1.1.1, WT2.1.1, TD5.2, TD5.1, TD2.2.1) and from controls (MINV5.1, WT6). The 2 expected isoforms of FGFR3 at 125 and 135 kd were observed in all tumor-bearing mice. Concomitantly, phosphorylated STAT3 and bcl-xL levels are increased coincident with elevations in FGFR3. The ERKgene is used as a housekeeping control on the lower panel.

FGFR3 is overexpressed and STAT3 and bcl-xLup-regulated in tumors originating after BM transplantation.

Western blot analysis for FGFR3 expression was performed on tissues derived from mice that developed tumors (WT1.1.1.1, WT2.1.1, TD5.2, TD5.1, TD2.2.1) and from controls (MINV5.1, WT6). The 2 expected isoforms of FGFR3 at 125 and 135 kd were observed in all tumor-bearing mice. Concomitantly, phosphorylated STAT3 and bcl-xL levels are increased coincident with elevations in FGFR3. The ERKgene is used as a housekeeping control on the lower panel.

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