Fig. 4.
The selective elimination of alloreactive donor T cells mitigates GVHD without compromising engraftment.
Irradiated AKR mice (850 cGy) were transplanted with TCD B6 BM alone (■, n = 9) or TCD BM plus 5 × 105 B6 TK+T cells with (▪, n = 16) or without (○, n = 13) GCV administered after transplantation. GCV was given to animals for either 5 (days 4-8, 2 experiments) or 10 (days 4-13, 1 experiment) days after transplantation and the results were combined. The mean weights of animals are depicted over the first 4 weeks.
