Fig. 5.
Donor T cells from GCV-treated mice are tolerant of host alloantigens.
Irradiated AKR mice (850 cGy) were transplanted with TCD B6 BM plus 5 × 105 B6 TK+ T cells. Mice were then treated with GCV from days 4 to 13 after transplantation. Four weeks after BMT, mice were killed and pooled spleen cells from these animals were cotransplanted with normal TCD B6 BM into lethally irradiated (1100 cGy) AKR hosts (▪, n = 6). Control groups consisted of similarly conditioned mice transplanted with TCD B6 BM alone (■, n = 4) or TCD B6 BM plus 5 × 105 B6 naive T cells (●, n = 5). Survival is depicted in panel A and serial weights in panel B.
