Repertoire analysis in a patient with viral relapse.

Longitudinal repertoire analysis of CD8⁺ PBMCs for patient T19. Treatment with the HIV protease inhibitor was interrupted after M6, and a viral rebound occurred. Between M0 and M20, a clear shift in repertoire usage is observed. Gray areas represent CD8 clonal expansions present at the onset of treatment. Black areas represent new dominant clonal expansions (not every overrepresented peak size is shaded; Figure 2 shows the count of the latter).