Pedigree of families 3 and 4.

(A) Family 3 harbors the 84-88 insC mutation. Genotypically affected patients are represented by filled symbols, unaffected relatives by open symbols. NE, not examined. (B) Pedigree of family 4. The genotypically affected patient is represented by a filled symbol, unaffected relatives by open symbols. The coinheritance of β-thalassemia is indicated by the asterisk.