Effect of postgrafting administration of G-CSF on recovery of antifungal T-cell responses in HLA-mismatched recipients of hematopoietic transplants.

Shown is a frequency analysis of C albicans–specific CD4⁺ cells in G-CSF–treated patients (A) and patients not treated with G-CSF (B) and of A fumigatus–specific CD4⁺ cells in G-CSF–treated patients (C) and patients not given the agent (D), as a function of time after grafting. The plots indicate the frequency of pathogen-specific T cells (y axis) as a function of time (x axis) after transplantation in G-CSF–treated patients (G-CSF+) and patients not treated with G-CSF (G-CSF−). C albicans–specific andA fumigatus–specific clonable CD4⁺ cells were determined by limiting-dilution asessments done monthly after transplantation. Fungus-specific T cells appeared earlier and at a higher frequency in patients not treated with G-CSF.