Survivin expression in reactive and B-CLL lymph nodes (immunoperoxidase staining).

In reactive lymph node follicles, only germinal center cells are Survivin⁺ (A and B at 100 × and 400 × magnifications in a case representative of the 4 studied). In a B-CLL lymph node completely effaced by malignant cells, a minority of cells, which are located in pseudofollicles, stain with anti-Survivin antibody (C and D, at 100 × and 400 × magnifications in a case representative of the 4 studied).