Fig. 2.
Whole blood coagulation and PGE1.
Comparison of whole blood coagulation in the absence (▪) and presence (●) of 5 μM PGE1. Coagulation was initiated in whole blood by 25 pM relipidated TF as described in “Materials and methods.” Panel A represents thrombin (TAT) generation, panel B fibrin (FPA) formation, and panels C and D platelet activation (osteonectin [ON] and PF4 release, respectively). Arrow “a” indicates clotting times for the control experiment, arrow “b” for the PGE1 experiment. Upper lane in panel D represents control experiment and lower lane represents PGE1experiment.