Fig. 2.
Fibrinogen inhibits thrombin-evoked elevations in [Ca++]i.
(A) Fura-2–loaded human platelets were stimulated with thrombin (0.1 U/mL) in the absence (Control) or presence of either fibrinogen alone (FG; 1 mg/mL) or fibrinogen after the addition of 100 μM RGDS (FG + RGDS). Traces are representative of 7 separate experiments.