Histologic analysis of laminin and fibrin(ogen) staining in BALB/c mice.

(A-C) Sections stained for fibrin(ogen) (brown) followed by hematoxylin (dark blue); (A) contralateral area of cerebral cortex with normal neuronal morphology (arrow) and diffuse fibrin(ogen) staining, which were comparable in the saline-treated and Pli-treated groups; (B,C) area of FII in saline-treated (B) and Pli-treated (C) mice. Neuronal morphology (arrows) and fibrin(ogen) staining are similarly affected in the saline-treated and Pli-treated groups. (D,H) Sections stained for laminin (dark blue); (D) contralateral area of cerebral cortex with strong immunoreactivity in basal lamina of vessels (arrowheads) and with immunoreactivity surrounding neurons (arrows), which were comparable in the saline-treated and Pli-treated groups; (E,F) area of FII in saline-treated (E) and Pli-treated (F) mice. The immunoreactivity of neurons (arrows) and vessels (arrowheads) in the infarct area was comparably reduced in both groups. Likewise, the immunoreactivity in neurons was reduced in the CA1 region of the hippocampus following injection of 1.5 nM kainic acid (H, arrows), relative to the contralateral side (G, arrows).