Fig. 2.
Alignment of MC and FCR3-CSA CIDR-1.
Alignment was performed by means of Clustalw software at:http://www.ebi.ac.uk/clustalw/. * indicates identical or conserved residues in all sequences in the alignment; :, conserved substitutions; and ., semiconserved substitutions. CIDR-1 domains have been divided into the M1, M2, and M3 regions, in which the M2 encompasses the minimal CD36-binding domain from theMCvar-1 CIDR-1. To exchange the regions of MC and FCR3-CSA CIDR-1, MluI, HindIII, andNdeI restriction sites were introduced. These modifications changed some amino acids at each site, as indicated under the sequences.