Fig. 2.
![Fig. 2. fVIII-Specific T-cell proliferative response is suppressed after blocking CD40-CD40L interaction in vivo. / T cells and peritoneal macrophages from 2 mice injected with fVIII (■) or 2 mice treated with anti-CD40L plus fVIII (●) were harvested at the end of the treatment and cocultured with increasing concentrations of fVIII. After 4 days, cells were pulsed with 1 μCi [3H]-thymidine, and incorporation of radioactivity was measured. Results are expressed as the mean of counts per minute (CPM) ± 1 SD of triplicate wells.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/97/9/10.1182_blood.v97.9.2750/6/h80911007002.jpeg?Expires=1735537629&Signature=0zWBY-gFg1og~Np6R0~Uaw1Ov4kmxIta-mCoy8rOu8witx4rkHEuBHMWASufmaUaexQGh8JWyQUIe94gnhY2W~zkN~wWWAXcb6I9tD1RydLPROQqiRkTUriIw~5lNL9mn29T29-4mT9s6LMU7oRfdwx4UpAp~bk-WUBAl~LSMFc2NFLdoz7Vi9L~U3tOi1Be9Jyxv3H8-11Vsy1lukeQJHj5kju5NSDk67Olk3vjOfFdT~NgQN~U91tHcNm47hMGDf4ewkPLJJYxYm5zKMqT5n2h39WjY-gasjeoCXOQ6Zoo45RnYSnD43ocevC08O8UquLzP3vDXJa3Z9aHtMX4ZA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
fVIII-Specific T-cell proliferative response is suppressed after blocking CD40-CD40L interaction in vivo.
T cells and peritoneal macrophages from 2 mice injected with fVIII (■) or 2 mice treated with anti-CD40L plus fVIII (●) were harvested at the end of the treatment and cocultured with increasing concentrations of fVIII. After 4 days, cells were pulsed with 1 μCi [3H]-thymidine, and incorporation of radioactivity was measured. Results are expressed as the mean of counts per minute (CPM) ± 1 SD of triplicate wells.
