Mean (± SE) plasma uric acid concentrations over time for all patients.

Squares denote patients who received rasburicase (n = 27) and stars allopurinol (n = 25). The 24 hours.post levels reflect 24 hours after the last dose of study drug. Patients who received rasburicase demonstrated more rapid decline and maintained lower plasma uric acid levels throughout the study period. The area under the serial plasma uric acid concentration curve through the first 96 hours of therapy was significantly less for patients receiving rasburicase (P < .0001).